3
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11337 |
Fumarate hydratase-IN-1
|
Mitochondrial Metabolism | Metabolism |
Fumarate hydratase-IN-1 是一种细胞可渗透性的富马酸水合酶抑制剂,具有抗增殖活性,可用于研究细胞活性。 | |||
T11336 |
Fumarate hydratase-IN-2 sodium salt
|
Others | Others |
Fumarate hydratase-IN-2 sodium salt (compound 3) 是一种具有细胞渗透性和竞争性的富马酸水合酶(fumarate hydratase)抑制剂 (Ki=4.5 μM),具有营养依赖性细胞毒性。 | |||
T71901 |
MP-1
|
||
MP-1 is a covalent inhibitor of fumarate hydratase (FH) that exhibits cytotoxicity dependent on FH. MP-1 engages a functional cysteine in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02003 |
FH/Fumarate Hydratase Protein, Human, Recombinant (His)
fumarate hydratase,MCL,LRCC,MCUL1,FMRD,HLR... |
Human | E. coli |
Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and func... | |||
TMPJ-00313 |
Fumarase Protein, Human, Recombinant
FH,Fumarase,Fumarate Hydratase Mitochondri... |
Human | E. coli |
Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy... |